American scientists have synthesized a remedy against premature death
American scientists from the Children's Heart Institute in Cincinnati tested the synthesized protein pUR4, which supports the functioning of the heart cells. It is shown that the drug is potentially able to effectively prevent repeated heart attacks and prolong life in children with heart defects. This is reported in a press release on MedicalXpress.
pUR4 blocks the activity of fibronectin, a protein that helps repair connective tissue after trauma. However, after heart attacks, fibronectin has a negative effect on vital tissues, replacing functional muscle cells with useless myofibroblasts. The molecule pUR4 is designed to suppress the formation of a matrix of fibronectin, which is used to create connective tissue.
The drug was tested on an animal model (mouse) and human heart cells. In rodents who had a heart attack, in the absence of treatment, a new agent developed fibrosis and the functions of the myocardium were disrupted. These effects were minimized in another group of mice who received molecular therapy with pUR4 for seven days after the infarction. A similar result was obtained using a culture of human cells.
According to scientists, it is necessary to conduct additional studies to check the safety and efficacy of the drug in large animals. Only after this, experts will pass to clinical trials involving people.