US scientists have found the cause of incurable obesity

Scientists at the University of California at San Diego have found out why people with obesity are struggling to get rid of excess weight. The culprit of this was the protein TBK1, which reduces the ability of cells to burn calories. This is reported in a press release of the study on MedicalXpress.

TBK1 or TANK-binding kinase 1 is an enzyme that is activated in response to inflammatory processes associated with obesity-related chronic stress. Kinase disables AMP-activated protein kinase (AMPK), which controls the energy balance in cells, blocks the synthesis of fatty acids and activates their oxidation. As a result, the body reduces energy costs, which makes it difficult to lose weight.

It is shown that in the cells there is a feedback loop, when activation of AMPK during fasting promotes the work of TBK1 inhibiting it. This also happens with inflammatory transcription factor NF-κB, which activates TBK1, but is itself suppressed by the latter, though not completely. With TBK1 disabled, the level of inflammatory responses in response to obesity increases.

It was shown that removal of TBK1 from the cell resulted in weight loss in mice with obesity and increased inflammation, but in rodents with normal weight there were no changes. In this case, amleksanoks - kinase inhibitor - promotes weight loss.
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